# High-Dose Melatonin’s Role In Cellular Energy, Detox & Healthy Aging | John Lieurance, ND, DC Source: https://myersdetox.com/johnlieurance/ Published: 2026-07-30 Summary: EP 655 High-Dose Melatonin’s Role In Cellular Energy, Detox & Healthy Aging | John Lieurance, ND, DC Facebook Twitter LinkedIn Subscribe to the Myers Detox Podcast: Apple YouTube Spotify In this episode… What if the fatigue, poor sleep, and slow healing you’ve chalked up to … ### EP 655 # High-Dose Melatonin’s Role In Cellular Energy, Detox & Healthy Aging | John Lieurance, ND, DC Facebook Twitter LinkedIn Listen to the episode: https://play.libsyn.com/embed/episode/id/42253670/height/192/theme/modern/size/large/thumbnail/yes/custom-color/ffffff/time-start/00:00:00/hide-playlist/yes/download/yes/font-color/000000 ### Subscribe to the Myers Detox Podcast: - [ Apple ](https://podcasts.apple.com/us/podcast/myers-detox-podcast/id1021418457) - [ YouTube ](https://www.youtube.com/@WendyMyers) - [ Spotify ](https://open.spotify.com/show/5xBtNTcvQuy2fSdvKPie79) ## In this episode… What if the fatigue, poor sleep, and slow healing you’ve chalked up to “just getting older” actually trace back to one molecule you stopped making enough of at 40? Melatonin isn’t just a sleep aid. It’s your mitochondria’s master antioxidant, and its levels fall off a cliff right when you need it most. In today’s episode, Dr. John Lieurance joins me to break down why that drop matters so much for energy, detox, and brain health. He shares the research behind super-physiological melatonin dosing, why suppositories outperform oral and IV delivery, and how melatonin clears heavy metals from the brain. We talk about his health crisis, root causes of enlarged prostate, and the peptides he uses for skin and tissue repair. We also dig into mold detox, craniosacral therapy, and heart rate variability as a longevity marker. ### Key discussion points… - Dr. Lieurance’s journey to health - Addressing prostate inflammation at the Advanced Rejuvenation clinic - The science of mitochondria and energy production - Mitochondrial stress from endogenous and exogenous toxins - Airways, dura and the glymphatic system - Fascia, acupuncture and frequency medicine - The Warburg effect and melatonin intersect - Pet products and high-dose melatonin therapy - How melatonin supports heavy metal detoxification - Suppositories and peak plasma - Melatonin and Heart Rate Variability (HRV) - Health benefits of MitoSkin and GHK-Cu Copper - Mold toxicity and detox strategies - Where to find Dr. Lieurance and work with him [ Read the Transcript From This Episode ](https://myersdetox.com/transcript655/) ### 400 times more melatonin is secreted by the lining of your gut, triggering microbiome swarming that stimulates the good bacteria to proliferate and inhibit the bad bacteria. Dr. John Lieurance ![quizz](https://myersdetox.com/wp-content/uploads/2024/05/quizz-img.jpg) ## How Toxic Are You? [Free Quiz] ### Are heavy metals making you sick? Heavy metal toxicity is often behind digestive issues, systemic infections, stubborn weight gain, brain fog, autoimmune disease, and chronic health conditions. [ Take the FREE Quiz Now! ](https://heavymetalsquiz.com/) ## Watch this Episode on YouTube: ## About Dr. John Lieurance Dr. John A. Lieurance, ND, DC, DABCN, is a Sarasota-based naturopathic physician, chiropractic neurologist, author, and educator with nearly 30 years of experience in functional medicine, regenerative medicine, and neurological care. He is the founder of Advanced Rejuvenation and serves as Scientific Advisor and Chief Formulator for MitoZen Scientific, where he focuses on mitochondrial health, advanced delivery systems, melatonin, NAD+, and methylene blue. Dr. Lieurance is widely known for his work with Functional Cranial Release, regenerative therapies, and his research-driven approach to supporting cellular energy, brain health, and whole-body vitality. Learn more about his work at [advancedrejuvenation.us ](https://www.advancedrejuvenation.us/)and buy his supplement line at [mitozen.com](https://www.mitozen.com/) - ## Resources Mentioned In This Episode ### [Dr. John Lieurance’s Book](https://a.co/d/04I0Zc2L) Melatonin’s sleep effect is receptor-mediated and saturates at 0.5–5 mg — which is why taking more does not help you sleep better. But melatonin is also a direct free-radical scavenger and a mitochondrial protector, and those effects are NOT receptor-mediated. They are concentration-dependent. Saturating tissue requires far more than saturating a receptor. That is the entire argument for high-dose melatonin, and this book makes it properly. [ Get your copy here ](https://a.co/d/04I0Zc2L) ### [MitoZen Supplements](https://www.mitozen.com/) Science-backed supplements for NAD+, sleep, immune support, cellular energy, and detoxification. [ Grab yours here ](https://www.mitozen.com/) ### [Fresh-Pressed Olive Oil](https://getfreshwendy.com) The health benefits of olive oil, from its antioxidants to polyphenols, are most potent when it’s fresh, but most supermarket olive oil is old and can even be rancid. I get my olive oil from the Fresh-Pressed Olive Oil Club, which sources artisanal oils directly from small farms and ships them to you right after they’re pressed. This ensures you’re getting the freshest, most nutrient-dense, and delicious olive oil possible. [ Try a full-size $39 bottle for just $1 to cover shipping ](https://getfreshwendy.com) ### [Tru Energy Skincare Bio Adaptive Hydration Oil](http://trytruenergy.com/wendy5) A bioactive, nourishing skin oil with a clean formulation designed to boost hydration and nourish the skin, helping to protect the skin barrier against elements like dry winter weather. It is infused with thousands of bio-energetic frequencies to support cellular repair, improve collagen production, and increase skin regeneration. [ Try the oil and save up to $197 ](http://trytruenergy.com/wendy5) ### [Organifi Collagen](https://organifi.com/myersdetox) A blend of five collagen types from four clean sources, rigorously tested for glyphosate, heavy metals, and purity. It supports joint mobility, skin firmness, gut repair, and overall vitality, especially important for women who can lose 30% of their collagen within the first few years of menopause. [ Save 20% with code MYERSDETOX ](https://organifi.com/myersdetox) ### Listen on: ## About Dr. Wendy Myers, ND: Dr. Wendy Myers, ND is a Naturopathic doctor and founder of Myersdetox.com. She is an internationally recognized expert on heavy metal detox, anti-aging and bioenergetics. She is a sought-after speaker, #1 bestselling author and the host of the top 50 rated podcast, the Myers Detox Podcast. Her mission is to educate and inspire the globe about topics related to anti-aging – detoxing from our increasingly toxic world to combat disease and increase longevity. - - - - - - - ## More Posts: ### [ #668 The Flower of Life: How Frequency and Sacred Geometry Can Upgrade Your Health | Brent Knudsen ](https://myersdetox.com/brentknudsen/) ### [ #667 Beyond Ozempic: The Peptides That Calm Inflammation and Fatigue and Promote Longevity | Awais Spall ](https://myersdetox.com/awaisspall-2/) ### [ #666 Chronic Fatigue Syndrome: How to Recover and Get Your Life back with Miguel Bautista ](https://myersdetox.com/miguelbautista/)